# RAS protein-specific guanine nucleotide-releasing factor 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28562634](https://www.wikidata.org/wiki/Q28562634)  
**Source**: https://4ort.xyz/entity/ras-protein-specific-guanine-nucleotide-releasing-factor-1-q28562634


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P28818)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28818)
5. [The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28818)
6. [Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28818)
7. [SCLIP, a microtubule-destabilizing factor, interacts with RasGRF1 and inhibits its ability to promote Rac activation and neurite outgrowth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28818)
8. [Requirement for Plk2 in Orchestrated Ras and Rap Signaling, Homeostatic Structural Plasticity, and Memory](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28818)
9. [Activity-dependent interaction of the intracellular domain of rat trkA with intermediate filament proteins, the beta-6 proteasomal subunit, Ras-GRF1, and the p162 subunit of eIF3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28818)
10. [A 54-kDa protein related to ras-guanine nucleotide release factor expressed in the rat exocrine pancreas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28818)
11. [Phosphorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28818)
12. [Amphetamine alters Ras-guanine nucleotide-releasing factor expression in the rat striatum in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28818)
13. [Hypoinsulinemia alleviates the GRF1/Ras/Akt anti-apoptotic pathway and induces alterations of mitochondrial ras trafficking in neuronal cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28818)
14. [p75-Ras-GRF1 is a c-Jun/AP-1 target protein: its up regulation results in increased Ras activity and is necessary for c-Jun-induced nonadherent growth of Rat1a cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28818)
15. [Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28818)
16. ensembl Release 104