# RAS p21 protein activator 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21104745](https://www.wikidata.org/wiki/Q21104745)  
**Source**: https://4ort.xyz/entity/ras-p21-protein-activator-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P20936)
3. Q20641742
4. [GAP domains responsible for ras p21-dependent inhibition of muscarinic atrial K+ channel currents](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
5. [Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
6. [Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
7. [Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
8. [The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
9. [A Ras-GTPase-activating protein SH3-domain-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
10. [Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
11. [ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
12. [Charting the molecular links between driver and susceptibility genes in colorectal cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
13. [Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
14. [Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
15. [Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
16. [Capns1, a new binding partner of RasGAP-SH3 domain in K-Ras(V12) oncogenic cells: modulation of cell survival and migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
17. [A quantitative protein interaction network for the ErbB receptors using protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
18. [Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
19. [Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27).](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
20. [GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
21. [A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
22. [p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
23. [In vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
24. [Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
25. [The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
26. [Binding of GAP to activated PDGF receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
27. [ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20936&geneProductId=UniProtKB:P20936)
28. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20936&geneProductId=UniProtKB:P20936)
29. [Regulation of the Ras signaling pathway by GTPase-activating protein in PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20936&geneProductId=UniProtKB:P20936)
30. [Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
31. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
32. [ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
33. [Regulation of the Ras signaling pathway by GTPase-activating protein in PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
34. [A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20936&geneProductId=UniProtKB:P20936)
35. [A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
36. [The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
37. [Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
38. [A novel RASA1 mutation causing capillary malformation-arteriovenous malformation (CM-AVM) presenting during pregnancy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
39. [Ras-GTPase activating protein (GAP): a putative effector for Ras](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
40. [Identification of amino acid residues of Ras protein that are essential for signal-transducing activity but not for enhancement of GTPase activity by GAP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
41. [Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936)
42. Ensembl Release 99
43. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)