# Rap guanine nucleotide exchange factor 3

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28561075](https://www.wikidata.org/wiki/Q28561075)  
**Source**: https://4ort.xyz/entity/rap-guanine-nucleotide-exchange-factor-3


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
4. [Microtubule-associated protein 1B-light chain 1 enhances activation of Rap1 by exchange protein activated by cyclic AMP but not intracellular targeting](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
5. [Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
6. [Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
7. [Radixin assembles cAMP effectors Epac and PKA into a functional cAMP compartment: role in cAMP-dependent cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
8. [Evidence for the involvement of cAMP-GEF (Epac) pathway in amylase release from the rat parotid gland](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
9. [Epac mediates cyclic AMP-dependent axon growth, guidance and regeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
10. [Renal expression of exchange protein directly activated by cAMP (Epac) 1 and 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
11. [Differential distribution of exchange proteins directly activated by cyclic AMP within the adult rat retina](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
12. [Interplay among cGMP, cAMP, and Ca2+ in living olfactory sensory neurons in vitro and in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
13. [Epac enhances excitation-transcription coupling in cardiac myocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
14. [PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
15. [Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
16. [Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
17. [Region-specific transcriptional response to chronic nicotine in rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
18. [Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
19. [EPAC expression and function in cardiac fibroblasts and myofibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
20. [Eight paths of ERK1/2 signalling pathway regulating hepatocyte proliferation in rat liver regeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
21. [Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
22. [Sustained Epac activation induces calmodulin dependent positive inotropic effect in adult cardiomyocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
23. [Protein kinase A-independent activation of ERK and H,K-ATPase by cAMP in native kidney cells: role of Epac I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
24. [Multiple treatments with L-3,4-dihydroxyphenylalanine modulate dopamine biosynthesis and neurotoxicity through the protein kinase A-transient extracellular signal-regulated kinase and exchange protein activation by cyclic AMP-sustained extracellular](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1C8)
25. ensembl Release 104