# Rap guanine nucleotide exchange factor 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21107982](https://www.wikidata.org/wiki/Q21107982)  
**Source**: https://4ort.xyz/entity/rap-guanine-nucleotide-exchange-factor-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9Y4G8)
3. Q20641742
4. [Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8)
5. [Membrane-associated guanylate kinase with inverted orientation (MAGI)-1/brain angiogenesis inhibitor 1-associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP/GTP exchange protein at tight junctions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8)
6. [Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8)
7. [nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8)
8. [Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8)
9. [JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8)
10. [RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8)
11. [RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8)
12. [Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4G8&geneProductId=UniProtKB:Q9Y4G8)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8)
14. [Rap2A links intestinal cell polarity to brush border formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8)
15. [The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8)
16. [Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8)
17. [PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8)
18. [Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8)
19. [The guanine nucleotide exchange factor CNrasGEF regulates melanogenesis and cell survival in melanoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8)
20. [Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8)
21. Ensembl Release 99