# Raf-1 proto-oncogene, serine/threonine kinase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q410434](https://www.wikidata.org/wiki/Q410434)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/C-Raf)  
**Source**: https://4ort.xyz/entity/raf-1-proto-oncogene-serine-threonine-kinase


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P04049)
4. Q20641742
5. Freebase Data Dumps. 2013
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
7. [Bcl-2 targets the protein kinase Raf-1 to mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
8. [Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04049&geneProductId=UniProtKB:P04049)
10. [Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04049&geneProductId=UniProtKB:P04049)
11. [Di-Ras, a distinct subgroup of ras family GTPases with unique biochemical properties](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
12. [FAM83B mediates EGFR- and RAS-driven oncogenic transformation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
13. [14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
14. [15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
15. [Binding of c-Raf1 Kinase to a Conserved Acidic Sequence within the Carboxyl-terminal Region of the HIV-1 Nef Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
16. [MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
17. [A NovelSHOC2Variant in Rasopathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
18. [FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
19. [Conserved oncogenic behavior of the FAM83 family regulates MAPK signaling in human cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
20. [Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
21. [Nuclear Raf‐1 kinase regulates the CXCR5 promoter by associating with NFATc3 to drive retinoic acid‐induced leukemic cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
22. [Identification of interaction between MEK2 and A-Raf-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
23. [Activation of Raf-1 by 14-3-3 proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
24. [14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
25. [The Prolyl Isomerase Pin1 Enhances HER-2 Expression and Cellular Transformation via Its Interaction with Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
26. [Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
27. [Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
28. [Spatial regulation of Raf kinase signaling by RKTG](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
29. [Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
30. [Structure homology and interaction redundancy for discovering virus-host protein interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
31. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
32. [Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
33. [Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
34. [Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
35. [Raf-1 is a binding partner of DSCR1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
36. [Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
37. [ERK and PDE4 cooperate to induce RAF isoform switching in melanoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
38. [Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
39. [Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
40. [Endothelial nitric oxide synthase regulates N-Ras activation on the Golgi complex of antigen-stimulated T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
41. [JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
42. [Identification of small-molecule inducers of pancreatic beta-cell expansion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
43. [Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
44. [Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
45. [Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
46. [RAF inhibitors that evade paradoxical MAPK pathway activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
47. [14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
48. [Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
49. [Regulation of RKIP binding to the N-region of the Raf-1 kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)
50. [Protein binding and signaling properties of RIN1 suggest a unique effector function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04049)