# Rac family small GTPase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4047929](https://www.wikidata.org/wiki/Q4047929)  
**Source**: https://4ort.xyz/entity/rac-family-small-gtpase-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P63000)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
6. [Nox1-dependent reactive oxygen generation is regulated by Rac1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
7. [The IQGAP-related protein DGAP1 interacts with Rac and is involved in the modulation of the F-actin cytoskeleton and control of cell motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
8. [Role of RacC for the regulation of WASP and phosphatidylinositol 3-kinase during chemotaxis of Dictyostelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
9. [Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
10. [BPAG1e maintains keratinocyte polarity through beta4 integrin-mediated modulation of Rac1 and cofilin activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
11. [The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
12. [The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
13. [CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
14. [Abba promotes PDGF-mediated membrane ruffling through activation of the small GTPase Rac1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
15. [Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
16. [Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
17. [Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
18. [The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
19. [The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
20. [The Rho Target PRK2 Regulates Apical Junction Formation in Human Bronchial Epithelial Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
21. [Structure and function of the intracellular region of the plexin-b1 transmembrane receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
22. [Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
23. [srGAP2 Arginine Methylation Regulates Cell Migration and Cell Spreading through Promoting Dimerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
24. [EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
25. [Rac1-induced cell migration requires membrane recruitment of the nuclear oncogene SET](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
26. [Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
27. [The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
28. [Crucial structural role for the PH and C1 domains of the Vav1 exchange factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
29. [A small GTPase‑like protein fragment of Mycoplasma promotes tumor cell migration and proliferation in vitro via interaction with Rac1 and Stat3.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
30. [Lowe syndrome protein OCRL1 interacts with Rac GTPase in the trans-Golgi network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
31. [DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
32. [Cytoplasmic targeting of the proto-oncogene SET promotes cell spreading and migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
33. [Rac1 Protein Rescues Neurite Retraction Caused by G2019S Leucine-rich Repeat Kinase 2 (LRRK2)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
34. [A palmitoylation switch mechanism regulates Rac1 function and membrane organization.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
35. [IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
36. [The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
37. [An organelle-specific protein landscape identifies novel diseases and molecular mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
38. [A human MAP kinase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
39. [Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
40. [Crystal structure of the Rac1-RhoGDI complex involved in nadph oxidase activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
41. [Nox1 activation by βPix and the role of Ser‐340 phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
42. [Adiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
43. [POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
44. [A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
45. [A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
46. [Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
47. [Identification of a novel Rac1-interacting protein involved in membrane ruffling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
48. [Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
49. [Caveolin-1 Mediates Salmonella Invasion via the Regulation of SopE-dependent Rac1 Activation and Actin Reorganization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)
50. [Invasion of breast cancer cells into collagen matrix requires TGF-α and Cdc42 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63000)