# R-spondin 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21988509](https://www.wikidata.org/wiki/Q21988509)  
**Source**: https://4ort.xyz/entity/r-spondin-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9Z132)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132)
5. [Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132)
6. [R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132)
8. [R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132)
9. [R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z132&geneProductId=UniProtKB:Q9Z132)
10. [Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z132&geneProductId=UniProtKB:Q9Z132)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z132&geneProductId=UniProtKB:Q9Z132)
12. [R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z132&geneProductId=UniProtKB:Q9Z132)
13. [RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z132)
14. ensembl Release 106