# Pyruvate kinase M1/2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116651](https://www.wikidata.org/wiki/Q21116651)  
**Source**: https://4ort.xyz/entity/pyruvate-kinase-m1-2-q21116651


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
4. [JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
5. [Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
6. [Modulation of M2‐type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
7. [Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
8. [Genome-wide YFP Fluorescence Complementation Screen Identifies New Regulators for Telomere Signaling in Human Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
9. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
10. [Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
11. [Novel raf kinase protein–protein interactions found by an exhaustive yeast two-hybrid analysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
12. [Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
13. [Huntingtin Interacting Proteins Are Genetic Modifiers of Neurodegeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
14. [Functional specialization of β-arrestin interactions revealed by proteomic analysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
15. [Isoform‐specific interaction of pyruvate kinase with hepatitis C virus NS5B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
16. [MHC class II‐associated proteins in B‐cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
17. [Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
18. [Isolation and characterization of the human pyruvate kinase M gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
19. [Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
20. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
21. [Identification of small molecule inhibitors of pyruvate kinase M2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
22. [Structural Basis for Tumor Pyruvate Kinase M2 Allosteric Regulation and Catalysis ,](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
23. [Structure and Function of Human Erythrocyte Pyruvate Kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
24. [Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
25. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
26. [Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
27. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
28. [MHC class II‐associated proteins in B‐cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
29. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
30. [Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
31. [Isolation and characterization of the human pyruvate kinase M gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
32. [Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
33. [Identification of small molecule inhibitors of pyruvate kinase M2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
34. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14618)
35. [Modulation of M2‐type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
36. [Proteomic analysis of cerebrospinal fluid extracellular vesicles: A comprehensive dataset](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
37. [Characterization of exosome‐like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
38. [Comparative Proteomic Analysis of Supportive and Unsupportive Extracellular Matrix Substrates for Human Embryonic Stem Cell Maintenance](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
39. [SILAC-Based Proteomics of Human Primary Endothelial Cell Morphogenesis Unveils Tumor Angiogenic Markers](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
40. [Phosphoproteome Analysis of Functional Mitochondria Isolated from Resting Human Muscle Reveals Extensive Phosphorylation of Inner Membrane Protein Complexes and Enzymes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
41. [Proteomic and Biochemical Analyses of Human B Cell-derived Exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
42. [Intestinal epithelial cells secrete exosome–like vesicles](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
43. [Proteomic Analysis of Human Parotid Gland Exosomes by Multidimensional Protein Identification Technology (MudPIT)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
44. [Large-Scale Proteomics and Phosphoproteomics of Urinary Exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
45. [Protein profile of exosomes from trabecular meshwork cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
46. [In‐depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
47. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
48. [Proteomic characterization of the human sperm nucleus](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
49. [Nuclear Translocation of the Tumor Marker Pyruvate Kinase M2 Induces Programmed Cell Death](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)
50. [Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=P14618&geneProductId=UniProtKB:P14618)