# Pyruvate dehydrogenase kinase 3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21123215](https://www.wikidata.org/wiki/Q21123215)  
**Source**: https://4ort.xyz/entity/pyruvate-dehydrogenase-kinase-3


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15120)
4. [Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15120&geneProductId=UniProtKB:Q15120)
5. [Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15120)
6. [Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15120)
7. [Diversity of the pyruvate dehydrogenase kinase gene family in humans](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15120&geneProductId=UniProtKB:Q15120)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15120&geneProductId=UniProtKB:Q15120)
9. [Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15120&geneProductId=UniProtKB:Q15120)
10. [Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15120&geneProductId=UniProtKB:Q15120)
11. [Diversity of the pyruvate dehydrogenase kinase gene family in humans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15120)
12. [Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15120)
13. [Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15120)
14. [Inactivation of the HIF-1α/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15120)
15. [Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15120)
16. Ensembl Release 99
17. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)