# Pyruvate dehydrogenase kinase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21123214](https://www.wikidata.org/wiki/Q21123214)  
**Source**: https://4ort.xyz/entity/pyruvate-dehydrogenase-kinase-2


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15119)
4. [Marked differences between two isoforms of human pyruvate dehydrogenase kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15119&geneProductId=UniProtKB:Q15119)
5. [Diversity of the pyruvate dehydrogenase kinase gene family in humans](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15119&geneProductId=UniProtKB:Q15119)
6. [Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15119)
7. [Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15119)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15119&geneProductId=UniProtKB:Q15119)
9. [Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15119&geneProductId=UniProtKB:Q15119)
10. [Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15119&geneProductId=UniProtKB:Q15119)
11. [Diversity of the pyruvate dehydrogenase kinase gene family in humans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15119)
12. [Marked differences between two isoforms of human pyruvate dehydrogenase kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15119)
13. [Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1α stabilization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15119)
14. [p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15119)
15. Ensembl Release 99
16. UMLS 2023