# Pyruvate dehydrogenase kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7118823](https://www.wikidata.org/wiki/Q7118823)  
**Source**: https://4ort.xyz/entity/pyruvate-dehydrogenase-kinase-1


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118)
4. [Diversity of the Pyruvate Dehydrogenase Kinase Gene Family in Humans](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15118&geneProductId=UniProtKB:Q15118)
5. [Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15118&geneProductId=UniProtKB:Q15118)
6. [Allosteric activation of the protein kinase PDK1 with low molecular weight compounds](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118)
7. [Mutagenesis Studies of the Phosphorylation Sites of Recombinant Human Pyruvate Dehydrogenase. SITE-SPECIFIC REGULATION](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118)
8. [An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118)
9. [Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15118&geneProductId=UniProtKB:Q15118)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15118&geneProductId=UniProtKB:Q15118)
11. [Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15118&geneProductId=UniProtKB:Q15118)
12. [Diversity of the Pyruvate Dehydrogenase Kinase Gene Family in Humans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118)
13. [Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118)
14. [Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118)
15. [Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118)
16. [Overexpression of Pyruvate Dehydrogenase Kinase 3 Increases Drug Resistance and Early Recurrence in Colon Cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15118)
17. Ensembl Release 99