# PYD and CARD domain containing

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116456](https://www.wikidata.org/wiki/Q21116456)  
**Source**: https://4ort.xyz/entity/pyd-and-card-domain-containing


## References

1. UniProt
2. Q20641742
3. [NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
4. [Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
5. [PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
6. [Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
7. [The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
8. [Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
9. [Overexpressed NLRC3 acts as an anti-inflammatory cytosolic protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
10. [AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
11. [Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
12. [ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
13. [PYPAF1, a PYRIN-containing Apaf1-like Protein That Assembles with ASC and Regulates Activation of NF-κB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
14. [Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
15. [Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
16. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
17. [Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
18. [Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
19. [Human Cytomegalovirus Tegument Protein pUL83 Inhibits IFI16-Mediated DNA Sensing for Immune Evasion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
20. [AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
21. [Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
22. [Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
23. [Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
24. [In silico prediction of physical protein interactions and characterization of interactome orphans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
25. [The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
26. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
27. [Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3)
28. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
29. [PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3)
30. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3)
31. [ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3)
32. [An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3)
33. [NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3)
34. [The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
35. [The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
36. [An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
37. [Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3)
38. [Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
39. [Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
40. [Central and overlapping role of Cathepsin B and inflammasome adaptor ASC in antigen presenting function of human dendritic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
41. [The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
42. [Cutting edge: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
43. [Mechanism and repertoire of ASC-mediated gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
44. [IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
45. [ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
46. [Mechanism of ASC-mediated apoptosis: bid-dependent apoptosis in type II cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
47. [ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
48. [ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3)
49. [PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULZ3)
50. [IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ULZ3&geneProductId=UniProtKB:Q9ULZ3)