Purinergic receptor P2X, ligand-gated ion channel, 7
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: P2X purinoreceptor extracellular domain superfamily
additional property: PropertyValue
  property ID: P361
  value: P2X7 purinoceptor
additional property: PropertyValue
  property ID: P637
  value: NP_001033928
additional property: PropertyValue
  property ID: P637
  value: NP_001033934
additional property: PropertyValue
  property ID: P637
  value: NP_001033976
additional property: PropertyValue
  property ID: P680
  value: ATP binding
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P680
  value: ion channel activity
additional property: PropertyValue
  property ID: P681
  value: integral component of membrane
additional property: PropertyValue
  property ID: P681
  value: integral component of nuclear inner membrane
additional property: PropertyValue
  property ID: P681
  value: soma
additional property: PropertyValue
  property ID: P682
  value: response to electrical stimulus
additional property: PropertyValue
  property ID: P682
  value: cellular response to organic cyclic compound
additional property: PropertyValue
  property ID: P682
  value: response to mechanical stimulus
additional property: PropertyValue
  property ID: P702
  value: P2rx7
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000098303
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000031425
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000083425
confidence:
  popularity graph score:
    score: 0.007
    score pct: 1
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 50
      unique citations norm: 0.02
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 50
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q9Z1M0
    source count: 1
    confidence: 0.2
  P361:
    value: Q24778773
    source count: 1
    confidence: 0.2
    value label: P2X purinoreceptor extracellular domain superfamily
  P361:
    value: Q24770180
    source count: 1
    confidence: 0.2
    value label: P2X7 purinoceptor
  P637:
    value: NP_001033928
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001033934
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001033976
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001271331
    source count: 1
    confidence: 0.2
  P637:
    value: NP_035157
    source count: 1
    confidence: 0.2
  P680:
    value: Q14817981
    source count: 2
    confidence: 0.4
    value label: ATP binding
  P680:
    value: Q167149
    source count: 1
    confidence: 0.2
    value label: protein binding
  P680:
    value: Q14864714
    source count: 1
    confidence: 0.2
    value label: ion channel activity
  P680:
    value: Q14864979
    source count: 1
    confidence: 0.2
    value label: lipopolysaccharide binding
  P680:
    value: Q21108843
    source count: 5
    confidence: 1.0
    value label: extracellularly ATP-gated cation channel activity
  P681:
    value: Q14327652
    source count: 1
    confidence: 0.2
    value label: integral component of membrane
  P681:
    value: Q14911834
    source count: 1
    confidence: 0.2
    value label: integral component of nuclear inner membrane
  P681:
    value: Q14645696
    source count: 2
    confidence: 0.4
    value label: soma
  P681:
    value: Q14873267
    source count: 1
    confidence: 0.2
    value label: cell-cell junction
  P681:
    value: Q14633850
    source count: 1
    confidence: 0.2
    value label: external side of plasma membrane
  P682:
    value: Q14820899
    source count: 1
    confidence: 0.2
    value label: response to electrical stimulus
  P682:
    value: Q14885641
    source count: 1
    confidence: 0.2
    value label: cellular response to organic cyclic compound
  P682:
    value: Q14864579
    source count: 1
    confidence: 0.2
    value label: response to mechanical stimulus
  P682:
    value: Q14914021
    source count: 1
    confidence: 0.2
    value label: phagolysosome assembly
  P682:
    value: Q14862717
    source count: 1
    confidence: 0.2
    value label: protein processing
  P702:
    value: Q18252869
    source count: 1
    confidence: 0.2
    value label: P2rx7
  P703:
    value: Q83310
    source count: 1
    confidence: 0.2
    value label: house mouse

value: ENSMUSP00000098303
source count: 1
confidence: 0.2

value: ENSMUSP00000031425
source count: 1
confidence: 0.2

value: ENSMUSP00000083425
source count: 1
confidence: 0.2

value: ENSMUSP00000112440
source count: 1
confidence: 0.2

value: ENSMUSP00000158311
source count: 1
confidence: 0.2

source: Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption
stated in qid: Q28594371
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptors
stated in qid: Q28590048
retrieved: 2019-02-14

source: Cutting edge: the nucleotide receptor P2X7 contains multiple protein- and lipid-interaction motifs including a potential binding site for bacterial lipopolysaccharide
stated in qid: Q28589722
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2018-07-16

source: Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption
stated in qid: Q28594371
retrieved: 2018-07-16

source: Properties of presynaptic P2X7-like receptors at the neuromuscular junction
stated in qid: Q28510680
retrieved: 2018-07-16

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-02-14

source: P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis
stated in qid: Q28510364
retrieved: 2019-02-14

source: Properties of presynaptic P2X7-like receptors at the neuromuscular junction
stated in qid: Q28510680
retrieved: 2019-02-14

source: P2X(7) receptor-mRNA and -protein in the mouse retina; changes during retinal degeneration in BALBCrds mice
stated in qid: Q28511703
retrieved: 2019-02-14

source: Characterization of a functional P2X(7)-like receptor in cerebellar granule neurons from P2X(7) knockout mice
stated in qid: Q28586043
retrieved: 2019-02-14

source: P2X7 receptor expression levels determine lethal effects of a purine based danger signal in T lymphocytes
stated in qid: Q28591628
retrieved: 2019-02-14

source: Synaptic terminals from mice midbrain exhibit functional P2X7 receptor
stated in qid: Q28504863
retrieved: 2019-02-14

source: Cloning and functional characterisation of the mouse P2X7 receptor
stated in qid: Q28512436
retrieved: 2019-02-14

source: Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor-/- mice
stated in qid: Q28591301
retrieved: 2019-02-14

source: Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses
stated in qid: Q28587004
retrieved: 2019-02-14

source: The P2X7 nucleotide receptor mediates skeletal mechanotransduction
stated in qid: Q28586177
retrieved: 2019-02-14

source: ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion
stated in qid: Q28587109
retrieved: 2019-02-14

source: Altered cytokine production in mice lacking P2X(7) receptors
stated in qid: Q28586061
retrieved: 2019-02-14

source: The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes
stated in qid: Q28584701
retrieved: 2019-02-14

source: ATP-induced apoptosis of thymocytes is mediated by activation of P2 X 7 receptor and involves de novo ceramide synthesis and mitochondria
stated in qid: Q28594653
retrieved: 2019-02-14

source: P2X7 receptor mediated phosphorylation of p38MAP kinase in the hippocampus
stated in qid: Q28590060
retrieved: 2019-02-14

source: Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia
stated in qid: Q28588931
retrieved: 2019-02-14

source: Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation
stated in qid: Q28591668
retrieved: 2019-02-14

source: A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death
stated in qid: Q28513626
retrieved: 2019-02-14

source: Nucleotide receptor signaling in murine macrophages is linked to reactive oxygen species generation
stated in qid: Q28513396
retrieved: 2019-02-14

source: P2X7 receptors regulate NKT cells in autoimmune hepatitis
stated in qid: Q28512178
retrieved: 2019-02-14

source: High sensitivity of CD4+CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors
stated in qid: Q28592075
retrieved: 2019-02-14

source: Cutting edge: purinergic signaling regulates radical-mediated bacterial killing mechanisms in macrophages through a P2X7-independent mechanism
stated in qid: Q28507148
retrieved: 2019-02-14

wikidata id: Q21990432
domain: protein
level: standard
html url: https://4ort.xyz/entity/purinergic-receptor-p2x-ligand-gated-ion-channel-7
markdown url: https://4ort.xyz/entity/purinergic-receptor-p2x-ligand-gated-ion-channel-7.md
facts url summary: https://4ort.xyz/entity/purinergic-receptor-p2x-ligand-gated-ion-channel-7/facts.json
facts url standard: https://4ort.xyz/entity/purinergic-receptor-p2x-ligand-gated-ion-channel-7/facts.json
facts url full: https://4ort.xyz/entity/purinergic-receptor-p2x-ligand-gated-ion-channel-7/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-02T06:31:57.513151Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:12:24.892497+00:00Z