# Purinergic receptor P2X, ligand-gated ion channel, 7

> mammalian protein found in Mus musculus

**Wikidata**: [Q21990432](https://www.wikidata.org/wiki/Q21990432)  
**Source**: https://4ort.xyz/entity/purinergic-receptor-p2x-ligand-gated-ion-channel-7


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9Z1M0)
3. Q20641742
4. [Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
6. [Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
7. [Cutting edge: the nucleotide receptor P2X7 contains multiple protein- and lipid-interaction motifs including a potential binding site for bacterial lipopolysaccharide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1M0&geneProductId=UniProtKB:Q9Z1M0)
9. [Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1M0&geneProductId=UniProtKB:Q9Z1M0)
10. [Properties of presynaptic P2X7-like receptors at the neuromuscular junction](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1M0&geneProductId=UniProtKB:Q9Z1M0)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
12. [P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
13. [Properties of presynaptic P2X7-like receptors at the neuromuscular junction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
14. [P2X(7) receptor-mRNA and -protein in the mouse retina; changes during retinal degeneration in BALBCrds mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
15. [Characterization of a functional P2X(7)-like receptor in cerebellar granule neurons from P2X(7) knockout mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
16. [P2X7 receptor expression levels determine lethal effects of a purine based danger signal in T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
17. [Synaptic terminals from mice midbrain exhibit functional P2X7 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
18. [Cloning and functional characterisation of the mouse P2X7 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
19. [Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor-/- mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
20. [Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
21. [The P2X7 nucleotide receptor mediates skeletal mechanotransduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
22. [ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
23. [Altered cytokine production in mice lacking P2X(7) receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
24. [The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
25. [ATP-induced apoptosis of thymocytes is mediated by activation of P2 X 7 receptor and involves de novo ceramide synthesis and mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
26. [P2X7 receptor mediated phosphorylation of p38MAP kinase in the hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
27. [Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
28. [Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
29. [A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
30. [Nucleotide receptor signaling in murine macrophages is linked to reactive oxygen species generation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
31. [P2X7 receptors regulate NKT cells in autoimmune hepatitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
32. [High sensitivity of CD4+CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
33. [Cutting edge: purinergic signaling regulates radical-mediated bacterial killing mechanisms in macrophages through a P2X7-independent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
34. [The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
35. [Role of sodium in mitochondrial membrane depolarization induced by P2X7 receptor activation in submandibular glands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
36. [TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
37. [Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
38. [Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
39. [Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
40. [Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
41. [Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
42. [P2X7 receptors mediate NADH transport across the plasma membranes of astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
43. [Exacerbation of experimental autoimmune encephalomyelitis in P2X7R-/- mice: evidence for loss of apoptotic activity in lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
44. [The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1M0&geneProductId=UniProtKB:Q9Z1M0)
45. [High sensitivity of CD4+CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1M0&geneProductId=UniProtKB:Q9Z1M0)
46. [Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1M0&geneProductId=UniProtKB:Q9Z1M0)
47. [Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
48. [P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
49. [P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0)
50. ensembl Release 106