# Purinergic receptor P2X 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21108844](https://www.wikidata.org/wiki/Q21108844)  
**Source**: https://4ort.xyz/entity/purinergic-receptor-p2x-4


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q99571)
4. Q20641742
5. [Go it alone no more--P2X7 joins the society of heteromeric ATP-gated receptor channels](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
6. [Histidine 140 plays a key role in the inhibitory modulation of the P2X4 nucleotide receptor by copper but not zinc](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
8. [P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
9. [A novel contractile phenotype with cardiac transgenic expression of the human P2X4 receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
10. [Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
11. [Site-specific splice variation of the human P2X4 receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
12. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
13. [Evidence for functional P2X4/P2X7 heteromeric receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
14. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
15. [Integral and associated lysosomal membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
16. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
17. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
18. [A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
19. [P2X(4) receptors mediate ATP-induced calcium influx in human vascular endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
20. [Fluid shear stress activates Ca(2+) influx into human endothelial cells via P2X4 purinoceptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
21. [A beneficial role of cardiac P2X4 receptors in heart failure: rescue of the calsequestrin overexpression model of cardiomyopathy](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
22. [Multiple P2X receptors are involved in the modulation of apoptosis in human mesangial cells: evidence for a role of P2X4](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
23. [ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
24. [Regenerative protein thymosin beta-4 is a novel regulator of purinergic signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571)
25. Ensembl Release 99
26. Transporter Classification database