# PTK2 protein tyrosine kinase 2 beta

> mammalian protein found in Mus musculus

**Wikidata**: [Q21985329](https://www.wikidata.org/wiki/Q21985329)  
**Source**: https://4ort.xyz/entity/ptk2-protein-tyrosine-kinase-2-beta


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9QVP9)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QVP9)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QVP9&geneProductId=UniProtKB:Q9QVP9)
6. [Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QVP9)
7. [Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QVP9&geneProductId=UniProtKB:Q9QVP9)
8. [Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QVP9)
9. [Leupaxin binds to PEST domain tyrosine phosphatase PEP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QVP9)
10. [Src kinase activity is essential for osteoclast function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QVP9)
11. [A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QVP9)
12. [Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QVP9)
13. [Mechanical Loading in Osteocytes Induces Formation of a Src/Pyk2/MBD2 Complex That Suppresses Anabolic Gene Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QVP9)
14. [The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QVP9)
15. [Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QVP9)
16. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QVP9)
17. [Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QVP9)
18. [Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QVP9)
19. [Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric oxide synthase-mediated angiogenic response and vascular function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QVP9)
20. [Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QVP9)
21. [Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QVP9)
22. ensembl Release 106