# PTEN induced kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21112306](https://www.wikidata.org/wiki/Q21112306)  
**Source**: https://4ort.xyz/entity/pten-induced-kinase-1


## References

1. UniProt
2. Q20641742
3. [Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
4. [Synaptic vesicle trafficking and Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
6. [Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
7. [BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
8. [PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
9. [Oxidative Stress-Induced Signaling Pathways Implicated in the Pathogenesis of Parkinson’s Disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
10. [Ubiquitin is phosphorylated by PINK1 to activate parkin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
11. [Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
12. [PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
13. [PINK1 cleavage at position A103 by the mitochondrial protease PARL.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
14. [Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
15. [Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
16. [BAG5 Protects against Mitochondrial Oxidative Damage through Regulating PINK1 Degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
17. [A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
18. [The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
19. [PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
20. [Cytosolic cleaved PINK 1 represses P arkin translocation to mitochondria and mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
21. [PINK1-dependent recruitment of Parkin to mitochondria in mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
22. [Phospho-tyrosine dependent protein-protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
23. [PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
24. [The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
25. [PINK1 protein in normal human brain and Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
26. [PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
27. [The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
28. [Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
29. [Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
30. [Hereditary early-onset Parkinson's disease caused by mutations in PINK1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
31. [The kinase domain of mitochondrial PINK1 faces the cytoplasm](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
32. [High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
33. [PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
34. [Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
35. [Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
36. [Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
37. [Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
38. [Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
39. [Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
40. [Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
41. [Increase of oxidative stress by a novel PINK1 mutation, P209A](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
42. [Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
43. [Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
44. [The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
45. [Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
46. [Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXM7&geneProductId=UniProtKB:Q9BXM7)
47. Ensembl Release 99