# Protein tyrosine phosphatase receptor type C

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4046258](https://www.wikidata.org/wiki/Q4046258)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/PTPRC)  
**Source**: https://4ort.xyz/entity/protein-tyrosine-phosphatase-receptor-type-c


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P08575)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
5. [SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
6. [Association of CD2 and CD45 on human T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
7. [Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
8. [The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
9. [Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
10. [Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
11. [Integrin CD11a cytoplasmic tail interacts with the CD45 membrane-proximal protein tyrosine phosphatase domain 1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
12. [Large-scale structural analysis of the classical human protein tyrosine phosphatome](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
13. [The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
14. [Subdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
15. [Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
16. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
17. [Structural variants of human T200 glycoprotein (leukocyte-common antigen)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
18. [Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
19. [Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
20. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
21. [FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
22. [The role of CD45 in the activation, proliferation and differentiation of human B lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
23. [CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
24. [CD45 regulates homing and engraftment of immature normal and leukemic human cells in transplanted immunodeficient mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
25. [Regulation of integrin-mediated T cell adhesion by the transmembrane protein tyrosine phosphatase CD45](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
26. [CD45: direct and indirect government of immune regulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08575&geneProductId=UniProtKB:P08575)
27. Ensembl Release 99