# Protein tyrosine phosphatase non-receptor type 22

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21114040](https://www.wikidata.org/wiki/Q21114040)  
**Source**: https://4ort.xyz/entity/protein-tyrosine-phosphatase-non-receptor-type-22-q21114040


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9Y2R2)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2)
5. [Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2)
6. [Large-scale structural analysis of the classical human protein tyrosine phosphatome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2)
7. [Proline-serine-threonine phosphatase interacting protein 1 inhibition of T-cell receptor signaling depends on its SH3 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2)
8. [The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2)
9. [Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2)
10. [The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2)
11. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2)
12. [Identification of substrates of human protein-tyrosine phosphatase PTPN22](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2)
13. [Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2)
14. [Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2)
15. [Research progress of several protein tyrosine phosphatases in diabetes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2)
16. [Subcellular localization of intracellular protein tyrosine phosphatases in T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2)
17. [PTPN22 gene regulates natural killer cell proliferation during in vitro expansion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2)
18. [Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2)
19. [Identification of a variant form of tyrosine phosphatase LYP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2)
20. [Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2R2)
21. Ensembl Release 99