# Protein tyrosine phosphatase non-receptor type 11

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7120997](https://www.wikidata.org/wiki/Q7120997)  
**Source**: https://4ort.xyz/entity/protein-tyrosine-phosphatase-non-receptor-type-11-q7120997


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q06124)
3. [Source](https://meshb.nlm.nih.gov/#/record/ui?ui=D054592)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
6. [The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
7. [Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
8. [FCRL6 receptor: expression and associated proteins.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
9. [Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
10. [The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
11. [Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
12. [Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
13. [Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
14. [Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
15. [FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
16. [An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
17. [GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
18. [Identification of CD112R as a novel checkpoint for human T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
19. [The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
20. [Identification of CLEC12B, an inhibitory receptor on myeloid cells.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
21. [Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
22. [A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
23. [A quantitative protein interaction network for the ErbB receptors using protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
24. [Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
25. [Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
26. [Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
27. [Identification of protein tyrosine phosphatases associating with the PDGF receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
28. [Localization of the Insulin-like Growth Factor I Receptor Binding Sites for the SH2 Domain Proteins p85, Syp, and GTPase Activating Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
29. [A2 isoform of mammalian translation factor eEF1A displays increased tyrosine phosphorylation and ability to interact with different signalling molecules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
30. [HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
31. [Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
32. [Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
33. [Identification of natural ligands for SH2 domains from a phage display cDNA library](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
34. [Roles of the Complex Formation of SHPS-1 with SHP-2 in Insulin-stimulated Mitogen-activated Protein Kinase Activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
35. [Fine specificity and molecular competition in SLAM family receptor signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
36. [An ITIM-like motif within the CCK2 receptor sequence required for interaction with SHP-2 and the activation of the AKT pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
37. [The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
38. [Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
39. [Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
40. [Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
41. [SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
42. [A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
43. [Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
44. [Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
45. [The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
46. [Interaction of SH2-containing protein tyrosine phosphatase 2 with the insulin receptor and the insulin-like growth factor-I receptor: studies of the domains involved using the yeast two-hybrid system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
47. [Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
48. [Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
49. [Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)
50. [Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124)