# Protein tyrosine phosphatase, non-receptor type 11

> mammalian protein found in Mus musculus

**Wikidata**: [Q14905498](https://www.wikidata.org/wiki/Q14905498)  
**Source**: https://4ort.xyz/entity/protein-tyrosine-phosphatase-non-receptor-type-11-q14905498


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P35235)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
5. [Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
6. [Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
7. [An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
8. [Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
9. [BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
10. [Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
11. [The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
12. [FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
13. [Gab3, a New DOS/Gab Family Member, Facilitates Macrophage Differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
14. [The murine ortholog of the SHP-2 binding molecule, PZR accelerates cell migration on fibronectin and is expressed in early embryo formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
15. [B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
16. [Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
17. [Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
18. [The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
19. [Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
20. [Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
21. [Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
22. [Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
23. [Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
24. [Site-Specific Incorporation of a Phosphotyrosine Mimetic Reveals a Role for Tyrosine Phosphorylation of SHP-2 in Cell Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
25. [Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
26. [B cell antigen receptor (BCR)-mediated formation of a SHP-2-pp120 complex and its inhibition by Fc gamma RIIB1-BCR coligation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
27. [Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
28. [LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
29. [SHP-2 is a novel target of Abl kinases during cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
30. [ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
31. [Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
32. [Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
33. [Role of the Protein Tyrosine Phosphatase Shp2 in Homeostasis of the Intestinal Epithelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
34. [SHP-2 mediates target-regulated axonal termination and NGF-dependent neurite growth in sympathetic neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
35. [DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
36. [Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35235)
37. ensembl Release 106