# Protein tyrosine kinase 6

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21114361](https://www.wikidata.org/wiki/Q21114361)  
**Source**: https://4ort.xyz/entity/protein-tyrosine-kinase-6


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13882)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
5. [Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13882&geneProductId=UniProtKB:Q13882)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13882&geneProductId=UniProtKB:Q13882)
7. [Sik (BRK) Phosphorylates Sam68 in the Nucleus and Negatively Regulates Its RNA Binding Ability](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13882&geneProductId=UniProtKB:Q13882)
8. [Regulated Association of Protein Kinase B/Akt with Breast Tumor Kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
9. [Sik (BRK) Phosphorylates Sam68 in the Nucleus and Negatively Regulates Its RNA Binding Ability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
10. [Identification of STAT3 as a specific substrate of breast tumor kinase.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
11. [Brk Activates Rac1 and Promotes Cell Migration and Invasion by Phosphorylating Paxillin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
12. [BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
13. [A Proteome-Scale Map of the Human Interactome Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
14. [Enhanced Prediction of Src Homology 2 (SH2) Domain Binding Potentials Using a Fluorescence Polarization-derived c-Met, c-Kit, ErbB, and Androgen Receptor Interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
15. [In situ quantification of HER2–protein tyrosine kinase 6 (PTK6) protein–protein complexes in paraffin sections from breast cancer tissues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
16. [Brk is coamplified with ErbB2 to promote proliferation in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
17. [Structural basis of the auto-inhibition mechanism of nonreceptor tyrosine kinase PTK6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
18. [Solution Structure and Backbone Dynamics of the Non-receptor Protein-tyrosine Kinase-6 Src Homology 2 Domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
20. [Breast Tumor Kinase Phosphorylates p190RhoGAP to Regulate Rho and Ras and Promote Breast Carcinoma Growth, Migration, and Invasion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
21. [The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
22. [PTK6 Inhibits Down-regulation of EGF Receptor through Phosphorylation of ARAP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
23. [Protein Tyrosine Kinase 6 Directly Phosphorylates AKT and Promotes AKT Activation in Response to Epidermal Growth Factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
24. [STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
25. [Brk/Protein Tyrosine Kinase 6 Phosphorylates p27 KIP1 , Regulating the Activity of Cyclin D–Cyclin-Dependent Kinase 4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
26. [Protein-tyrosine Kinase 6 Promotes Peripheral Adhesion Complex Formation and Cell Migration by Phosphorylating p130 CRK-associated Substrate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
27. [Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
28. [Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
29. [Regulation of the Nonreceptor Tyrosine Kinase Brk by Autophosphorylation and by Autoinhibition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
30. [Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13882)
31. Ensembl Release 99