# protein tyrosine kinase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q2744706](https://www.wikidata.org/wiki/Q2744706)  
**Source**: https://4ort.xyz/entity/protein-tyrosine-kinase-2


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3137331)
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3040440)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q05397)
5. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/H0YB16)
6. Q20641742
7. Freebase Data Dumps. 2013
8. [Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05397&geneProductId=UniProtKB:Q05397)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:H0YB16)
12. [Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
13. [Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05397&geneProductId=UniProtKB:Q05397)
14. [Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05397&geneProductId=UniProtKB:Q05397)
15. [A novel Cas family member, HEPL, regulates FAK and cell spreading](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
16. [Protein complexes involving alpha v beta 3 integrins, nonmuscle myosin heavy chain-A, and focal adhesion kinase from in thrombospondin-treated smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
17. [Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
18. [Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
19. [LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
20. [Functional consequences of interactions between FAK and epithelial membrane protein 2 (EMP2)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
21. [Epithelial Membrane Protein-2 Promotes Endometrial Tumor Formation through Activation of FAK and Src](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
22. [The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
23. [The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
24. [TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
25. [Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
26. [Linker length dependent binding of a focal adhesion kinase derived peptide to the Src SH3-SH2 domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
27. [The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
28. [Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
29. [Cyanidin-3-Glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
30. [Role of p53/FAK association and p53Ser46 phosphorylation in staurosporine-mediated apoptosis: wild type versus mutant p53-R175H](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
31. [Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
32. [Inhibition of T24 human bladder carcinoma cell migration by RNA interference suppressing the expression of HD-PTP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
33. [Activation of focal adhesion kinase through an interaction with β4 integrin contributes to tumorigenicity of colon cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
34. [FAK promotes recruitment of talin to nascent adhesions to control cell motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
35. [Proinvasion metastasis drivers in early-stage melanoma are oncogenes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
36. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
37. [Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
38. [p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
39. [Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
40. [Mobility of TOAC spin-labelled peptides binding to the Src SH3 domain studied by paramagnetic NMR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
41. [Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
42. [Interaction of Hic-5, A Senescence-related Protein, with Focal Adhesion Kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
43. [Phospho-tyrosine dependent protein-protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
44. [Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
45. [Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
46. [Activation of rapid oestrogen signalling in aggressive human breast cancers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
47. [Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
48. [A directed protein interaction network for investigating intracellular signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
49. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)
50. [Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397)