# protein tyrosine kinase 2 beta

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21101275](https://www.wikidata.org/wiki/Q21101275)  
**Source**: https://4ort.xyz/entity/protein-tyrosine-kinase-2-beta


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3137331)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q14289)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
7. [A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289)
8. [Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289)
9. [Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289)
10. [Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
11. [Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
12. [The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
13. [A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
14. [Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
15. [Negative regulation of PYK2/related adhesion focal tyrosine kinase signal transduction by hematopoietic tyrosine phosphatase SHPTP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
16. [Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289)
17. [Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
18. [The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
19. [A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
20. [Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
21. [Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
22. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
23. [Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
24. [Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289)
25. [Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
26. [Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
27. [Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
28. [Fyn inhibition rescues established memory and synapse loss in Alzheimer mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
29. [Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
30. [Activation of Pyk2 by stress signals and coupling with JNK signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
31. [Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
32. [Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
33. [Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289)
34. [Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
35. [SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
36. [Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
37. [A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289)
38. [Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14289&geneProductId=UniProtKB:Q14289)
39. [Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
40. [A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14289)
41. Ensembl Release 99
42. UMLS 2023