# Protein tyrosine kinase 2 beta

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28559587](https://www.wikidata.org/wiki/Q28559587)  
**Source**: https://4ort.xyz/entity/protein-tyrosine-kinase-2-beta-q28559587


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P70600)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
5. [Survival response-linked Pyk2 activation during potassium depletion-induced apoptosis of cerebellar granule neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
6. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
7. [Suppression of Pyk2 attenuated the increased tyrosine phosphorylation of NMDA receptor subunit 2A after brain ischemia in rat hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
8. [Role of p38 map kinase in glycine-induced hepatocyte resistance to hypoxic injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
9. [Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
10. [Adapter protein CRKII signaling is involved in the rat pancreatic acini response to reactive oxygen species](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
11. [The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
12. [RAFTK/Pyk2 regulates EGF-induced PC12 cell spreading and movement](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
13. [Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
14. [Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
15. [Integrins regulate opioid receptor signaling in trigeminal ganglion neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
16. [Proline-rich tyrosine kinase2 is involved in F-actin organization during in vitro maturation of rat oocyte](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
17. [Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
18. [CAKbeta/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
19. [Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
20. [FAK+ and PYK2/CAKbeta, two related tyrosine kinases highly expressed in the central nervous system: similarities and differences in the expression pattern](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
21. [Depolarization activates ERK and proline-rich tyrosine kinase 2 (PYK2) independently in different cellular compartments in hippocampal slices](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
22. [Integrin Dynamics Produce a Delayed Stage of Long-Term Potentiation and Memory Consolidation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
23. [Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
24. [Reactive oxygen species mediate Endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 signaling, as well as protein synthesis, in vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
25. [Pyk2/CAKβ Tyrosine Kinase Activity-mediated Angiogenesis of Pulmonary Vascular Endothelial Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
26. [Calcium-dependent activation of Pyk2 by hypoxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
27. [Osmotic stress induces HB-EGF gene expression via Ca(2+)/Pyk2/JNK signal cascades in rat aortic smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
28. [Signal transduction of physiological concentrations of vasopressin in A7r5 vascular smooth muscle cells. A role for PYK2 and tyrosine phosphorylation of K+ channels in the stimulation of Ca2+ spiking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
29. [Arginine vasopressin stimulates mesangial cell proliferation by activating the epidermal growth factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
30. [The Src family kinase, Lyn, is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters and growth factors which stimulate its association with numerous other signaling molecules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
31. [Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
32. [Lithium suppressed Tyr-402 phosphorylation of proline-rich tyrosine kinase (Pyk2) and interactions of Pyk2 and PSD-95 with NR2A in rat hippocampus following cerebral ischemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
33. [Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
34. [Antiapoptotic effect of endothelin-1 in rat cardiomyocytes in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
35. [Stromal cell-derived factor-1alpha induces astrocyte proliferation through the activation of extracellular signal-regulated kinases 1/2 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
36. [Cerebral ischemia and seizures induce tyrosine phosphorylation of PYK2 in neurons and microglial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
37. [Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
38. [Ca(2+)-sensitive tyrosine kinase Pyk2/CAK beta-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
39. [Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
40. [PYK2 signaling is required for PDGF-dependent vascular smooth muscle cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
41. [Antidepressant effect of the calcium-activated tyrosine kinase Pyk2 in the lateral septum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
42. [Changes in rat frontal cortex gene expression following chronic cocaine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
43. [Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
44. [Mitochondrial signals initiate the activation of c-Jun N-terminal kinase (JNK) by hypoxia-reoxygenation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
45. [Losartan improves aortic endothelium-dependent relaxation via proline-rich tyrosine kinase 2/Src/Akt pathway in type 2 diabetic Goto-Kakizaki rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
46. [Chronic ethanol feeding impairs endothelin-1-stimulated glucose uptake via decreased G alpha 11 expression in rat adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
47. [A role for PYK2 in ANG II-dependent regulation of the PHAS-1-eIF4E complex by multiple signaling cascades in vascular smooth muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
48. [Divergent regulation of Pyk2/CAKbeta phosphorylation by Ca2+ and cAMP in the hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
49. [Proline-rich tyrosine kinase 2 regulates hippocampal long-term depression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70600)
50. ensembl Release 106