# Protein kinase, DNA-activated, catalytic subunit

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21105070](https://www.wikidata.org/wiki/Q21105070)  
**Source**: https://4ort.xyz/entity/protein-kinase-dna-activated-catalytic-subunit


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P78527)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
5. [Phosphorylation and Regulation of DNA Ligase IV Stability by DNA-dependent Protein Kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
6. [A Role of DNA-PK for the Metabolic Gene Regulation in Response to Insulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527)
8. [DNA Damage Triggers Golgi Dispersal via DNA-PK and GOLPH3](http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527)
9. [A Role of DNA-PK for the Metabolic Gene Regulation in Response to Insulin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527)
10. [DNA-dependent Protein Kinase Interacts with Antigen Receptor Response Element Binding Proteins NF90 and NF45](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
11. [XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
12. [Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
13. [Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
14. [DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
15. [Enhancer Activation Requires trans-Recruitment of a Mega Transcription Factor Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
16. [Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
17. [Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
18. [A Role for the HOXB7 Homeodomain Protein in DNA Repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
19. [A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
20. [DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
21. [DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
22. [Aire's Partners in the Molecular Control of Immunological Tolerance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
23. [Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
24. [Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
25. [A YY1–INO80 complex regulates genomic stability through homologous recombination–based repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
26. [Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
27. [The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
28. [Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
29. [TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
30. [Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527)
31. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527)
32. [DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
33. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
34. [Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
35. [DNA Damage Triggers Golgi Dispersal via DNA-PK and GOLPH3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
36. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
37. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527)
38. [Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
39. [SILAC-Based Proteomics of Human Primary Endothelial Cell Morphogenesis Unveils Tumor Angiogenic Markers](http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527)
40. [Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527)
41. [PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
42. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
43. [The Catalytic Subunit of DNA-Dependent Protein Kinase Regulates Proliferation, Telomere Length, and Genomic Stability in Human Somatic Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
44. [The Catalytic Subunit of DNA-Dependent Protein Kinase Regulates Proliferation, Telomere Length, and Genomic Stability in Human Somatic Cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527)
45. [HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527)
46. Ensembl Release 99
47. Identifiers.org