# Protein kinase C theta

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21110503](https://www.wikidata.org/wiki/Q21110503)  
**Source**: https://4ort.xyz/entity/protein-kinase-c-theta-q21110503


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL565612)
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL494089)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q04759)
5. Q20641742
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
7. [Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
8. [A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
9. [The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
10. [Direct interaction in T-cells between thetaPKC and the tyrosine kinase p59fyn](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
11. [PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
12. [Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
13. [Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
14. [Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04759&geneProductId=UniProtKB:Q04759)
16. [Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04759&geneProductId=UniProtKB:Q04759)
17. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04759&geneProductId=UniProtKB:Q04759)
18. [Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04759&geneProductId=UniProtKB:Q04759)
19. [Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
20. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
21. [Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
22. [Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
23. [High-throughput RNAi screening reveals novel regulators of telomerase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
24. [Protein kinase C-theta-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
25. [Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
26. [Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
27. [Phosphorylation of the CARMA1 linker controls NF-kappaB activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
28. [CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04759)
29. Ensembl Release 99