# Protein kinase C iota

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109253](https://www.wikidata.org/wiki/Q21109253)  
**Source**: https://4ort.xyz/entity/protein-kinase-c-iota-q21109253


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL565612)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL494089)
5. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P41743)
6. Q20641742
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
8. [Glyceraldehyde-3-phosphate Dehydrogenase Is Phosphorylated by Protein Kinase Cι/λ and Plays a Role in Microtubule Dynamics in the Early Secretory Pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41743&geneProductId=UniProtKB:P41743)
10. [Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41743&geneProductId=UniProtKB:P41743)
11. [Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41743&geneProductId=UniProtKB:P41743)
12. [Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
13. [A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
14. [WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
15. [Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell Polarity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
16. [Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
17. [Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
18. [Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
19. [NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
20. [mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
21. [A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
22. [Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
23. [The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
24. [A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
25. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
26. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
27. [GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
28. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
29. [Network organization of the human autophagy system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
30. [Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
31. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
32. [Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
33. [Evolutionary and molecular facts link the WWC protein family to Hippo signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
34. [Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
35. [Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
36. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
37. [PKC-ι promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphatidylinositol 3-kinase pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
38. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41743&geneProductId=UniProtKB:P41743)
39. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
40. [Overexpression of atypical PKC in PC12 cells enhances NGF-responsiveness and survival through an NF-kappaB dependent pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
41. [Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743)
42. Ensembl Release 99