# Protein kinase C alpha

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7119501](https://www.wikidata.org/wiki/Q7119501)  
**Source**: https://4ort.xyz/entity/protein-kinase-c-alpha


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL565612)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL494089)
5. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P17252)
6. Q20641742
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
8. [Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
9. [Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
10. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17252)
11. [Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17252)
12. [Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17252)
13. [Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17252)
14. [Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17252)
15. [The A-kinase anchoring protein 15 regulates feedback inhibition of the epithelial Na+ channel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
16. [Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
17. [Protein kinase C alpha-mediated phosphorylation of PIM-1L promotes the survival and proliferation of acute myeloid leukemia cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
18. [Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
19. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
20. [PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
21. [The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
22. [Direct binding of syndecan-4 cytoplasmic domain to the catalytic domain of protein kinase C alpha (PKC alpha) increases focal adhesion localization of PKC alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
23. [The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
24. [Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
25. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17252&geneProductId=UniProtKB:P17252)
26. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
27. [Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
28. [Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
29. [Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
30. [Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
31. [Unraveling the Role of KIAA1199, a Novel Endoplasmic Reticulum Protein, in Cancer Cell Migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
32. [Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
33. [Calcitonin promotes outgrowth of trophoblast cells on endometrial epithelial cells: involvement of calcium mobilization and protein kinase C activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
34. [Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17252)
35. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17252)
36. [Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
37. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
38. [Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
39. [Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
40. [Induction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multiforme cells by a protein kinase Calpha antisense oligonucleotide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
41. [Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
42. [Protein kinase C-alpha modulates lipopolysaccharide-induced functions in a murine macrophage cell line](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
43. [Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
44. [A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
45. [Bryostatin 1 induces prolonged activation of extracellular regulated protein kinases in and apoptosis of LNCaP human prostate cancer cells overexpressing protein kinase calpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
46. [Direct Demonstration of Involvement of Protein Kinase Cα in the Ca2+-induced Platelet Aggregation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
47. [Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1/Kal-7/Rac1 “Signalosome”](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
48. [Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252)
49. Ensembl Release 99