# Protein kinase C, alpha

> mammalian protein found in Mus musculus

**Wikidata**: [Q14912658](https://www.wikidata.org/wiki/Q14912658)  
**Source**: https://4ort.xyz/entity/protein-kinase-c-alpha-q14912658


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P20444)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20444&geneProductId=UniProtKB:P20444)
6. [PKC-alpha regulates cardiac contractility and propensity toward heart failure](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20444&geneProductId=UniProtKB:P20444)
7. [Opposing regulatory roles of phosphorylation and acetylation in DNA mispair processing by thymine DNA glycosylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
8. [Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
9. [Rapid activation of CLOCK by Ca2+-dependent protein kinase C mediates resetting of the mammalian circadian clock](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
10. [A novel protein kinase C alpha-dependent signal to ERK1/2 activated by alphaVbeta3 integrin in osteoclasts and in Chinese hamster ovary (CHO) cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
11. [Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
12. [Regulation of mature T lymphocyte proliferation and differentiation by Par-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
13. [The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
14. [Identity in molecular structure between "differentiation enhancing factor" of murine erythroleukemia cells and the 30 kD heparin-binding protein of developing rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
15. [Expression and activity of protein kinase C isoenzymes during normal and abnormal murine palate development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
16. [PKC-alpha regulates cardiac contractility and propensity toward heart failure](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
17. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
18. [Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
19. [PKC signaling at fertilization in mammalian eggs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
20. [PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
21. [Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
22. [Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
23. [The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
24. [Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
25. [Cloning and immunocytochemical localization of a cyclic nucleotide-gated channel alpha-subunit to all cone photoreceptors in the mouse retina](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
26. [Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
27. [cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
28. [Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
29. [Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
30. [MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
31. [Knockout of PKC alpha enhances insulin signaling through PI3K](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
32. [PKCalpha regulates platelet granule secretion and thrombus formation in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
33. [Functional PKC in vivo analysis using deficient mouse models](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
34. [Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
35. [An activated protein kinase C alpha gives a differentiation signal for hematopoietic progenitor cells and mimicks macrophage colony-stimulating factor-stimulated signaling events](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
36. [Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
37. [Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
38. [Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
39. [Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20444)
40. ensembl Release 106
41. UMLS 2023