# Protection of telomeres 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21104947](https://www.wikidata.org/wiki/Q21104947)  
**Source**: https://4ort.xyz/entity/protection-of-telomeres-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9NUX5)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
5. [HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
6. [POT1 as a terminal transducer of TRF1 telomere length control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
7. [Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
8. [TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
9. [POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
10. [Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
11. [TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
12. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
13. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
14. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
15. [Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
16. [POT1 association with TRF2 regulates telomere length](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
17. [The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
18. [The POT1-TPP1 telomere complex is a telomerase processivity factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
19. [The human CST complex is a terminator of telomerase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
20. [PTOP interacts with POT1 and regulates its localization to telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
21. [POT1 and TRF2 cooperate to maintain telomeric integrity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
22. [TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
23. [The POT1-TPP1 telomere complex is a telomerase processivity factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5)
24. [The human CST complex is a terminator of telomerase activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5)
25. [Characterization of the DNA binding specificity of Shelterin complexes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5)
26. [Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5)
27. [Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
28. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
29. [Characterization of the DNA binding specificity of Shelterin complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
30. [A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5)
31. [A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
32. [Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
33. [Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
34. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5)
35. [POT1 and TRF2 cooperate to maintain telomeric integrity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5)
36. [Telomere protection by mammalian Pot1 requires interaction with Tpp1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5)
37. [RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
38. [ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NUX5&geneProductId=UniProtKB:Q9NUX5)
39. [Human POT1 facilitates telomere elongation by telomerase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
40. [Telomere protection by mammalian Pot1 requires interaction with Tpp1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
41. [ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NUX5)
42. ensembl Release 96