# Prostaglandin I2 synthase

> Enzyme found in humans

**Wikidata**: [Q904590](https://www.wikidata.org/wiki/Q904590)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Prostacyclin_synthase)  
**Source**: https://4ort.xyz/entity/prostaglandin-i2-synthase


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q16647)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647)
6. [The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647)
8. [Crystal structure of the human prostacyclin synthase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647)
9. [The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647)
10. [Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647)
12. [Crystal structure of the human prostacyclin synthase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647)
13. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647)
14. [Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647)
15. [Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: Mechanisms of COX-2 inhibitor risk to heart disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647)
16. [Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: Mechanisms of COX-2 inhibitor risk to heart disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16647&geneProductId=UniProtKB:Q16647)
17. [Prostacyclin-dependent apoptosis mediated by PPAR delta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647)
18. [Molecular cloning and expression of human prostacyclin synthase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647)
19. [Protection against cytokine toxicity through endoplasmic reticulum and mitochondrial stress prevention by prostacyclin synthase overexpression in insulin-producing cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16647)
20. Ensembl Release 99