# Prostaglandin-endoperoxide synthase 2

> human enzyme involved in inflammation

**Wikidata**: [Q415364](https://www.wikidata.org/wiki/Q415364)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Cyclooxygenase-2)  
**Source**: https://4ort.xyz/entity/prostaglandin-endoperoxide-synthase-2


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL154)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1034)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2107455)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1071)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1835207)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL25)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL521)
10. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL166863)
11. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL469)
12. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL53292)
13. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL139)
14. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL622)
15. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1077)
16. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1297)
17. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL898)
18. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL435298)
19. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200804)
20. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2103736)
21. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1201124)
22. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200806)
23. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200613)
24. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P35354)
25. Q20641742
26. Freebase Data Dumps. 2013
27. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354)
28. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354)
29. [Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354)
30. [Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354)
31. [Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354)
32. [Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354)
33. [Human cyclooxygenase-2 cDNA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354)
34. [Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354)
35. [Human cyclooxygenase-2 cDNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354)
36. [Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354)
37. [Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354)
38. [Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354)
39. [Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354)
40. Ensembl Release 99
41. Identifiers.org