# Prostaglandin-endoperoxide synthase 2

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28562584](https://www.wikidata.org/wiki/Q28562584)  
**Source**: https://4ort.xyz/entity/prostaglandin-endoperoxide-synthase-2-q28562584


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P35355)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
5. [Evidence for cyclooxygenase-2 association with caveolin-3 in primary cultured rat chondrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
6. [Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
7. [Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
8. [Expression and activity of cyclooxygenase isoforms in skeletal muscles and myocardium of humans and rodents](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
9. [Stimulation of tube formation mediated through the prostaglandin EP2 receptor in rat luteal endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
10. [Anti-inflammatory and analgesic actions of etoricoxib (an NSAID) combined with misoprostol](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
11. [Rat ovulation, implantation and decidualization are severely compromised by COX-2 inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
12. [Down-regulated CFTR During Aging Contributes to Benign Prostatic Hyperplasia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
13. [Neuroprotective Effect of Cyclooxygenase Inhibitors in ICV-STZ Induced Sporadic Alzheimer’s Disease in Rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
14. [COX-2, but not COX-1, activity is necessary for the induction of perforant path long-term potentiation and spatial learning in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
15. [Characterization of the prostaglandin E2 pathway in a rat model of esophageal adenocarcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
16. [Cyclooxygenase-2 Overexpression Inhibits Platelet-derived Growth Factor-induced Mesangial Cell Proliferation through Induction of the Tumor Suppressor Gene p53 and the Cyclin-dependent Kinase Inhibitors p21waf-1/cip-1 and p27kip-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
17. [Electroacupuncture inhibits cyclooxygenase-2 up-regulation in rat spinal cord after spinal nerve ligation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
18. [The protective role of Kangen-karyu against fructose-induced metabolic syndrome in a rat model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
19. [Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
20. [Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
21. [Chronic lithium downregulates cyclooxygenase-2 activity and prostaglandin E(2) concentration in rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
22. [Urethane suppresses rat lung inducible cyclooxygenase and nitric oxide synthase mRNA levels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
23. [Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
24. [Cyclooxygenase-2 contributes to VX-induced cell death in cultured cortical neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
25. [Insulin suppresses LPS-induced iNOS and COX-2 expression and NF-kappaB activation in alveolar macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
26. [Suppressing inflammatory cascade by cyclo-oxygenase inhibitors attenuates quinolinic acid induced Huntington's disease-like alterations in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
27. [P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
28. [Central control of fever and female body temperature by RANKL/RANK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
29. [Dopaminergic but not glutamatergic neurotransmission is increased in the striatum after selective cyclooxygenase-2 inhibition in normal and hemiparkinsonian rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
30. [Estrogen potentiates constrictor prostanoid function in female rat aorta by upregulation of cyclooxygenase-2 and thromboxane pathway expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
31. [The effect of adrenomedullin on the L-type calcium current in myocytes from septic shock rats: signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
32. [Selective inhibition of cyclooxygenase-2 (COX-2) by 1alpha,25-dihydroxy-16-ene-23-yne-vitamin D3, a less calcemic vitamin D analog](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
33. [Role of the tumor necrosis factor-alpha, cyclooxygenase-2, prostaglandin E2, and effect of low-intensity pulsed ultrasound in an in vitro herniated disc resorption model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
34. [Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF- B/COX-2/PGE2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
35. [Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
36. [Anti-inflammatory effects of celecoxib in rat lungs with smoke-induced emphysema](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
37. [Expression pattern of cyclooxygenase-2 in normal rat epidermis and pilosebaceous unit during hair cycle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
38. [Celecoxib after the onset of reperfusion reduces apoptosis in the amygdala](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
39. [Cyclooxygenase-dependent vasoconstricting factor(s) in remodelled rat femoral arteries](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
40. [Pathophysiology of motility dysfunction in bowel obstruction: role of stretch-induced COX-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
41. [The pathophysiological roles of COX-1 and COX-2 in the intestinal smooth muscle contractility under the anaphylactic condition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
42. [Upregulation of cyclooxygenase-2 by motorcycle exhaust particulate-induced reactive oxygen species enhances rat vascular smooth muscle cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
43. [LY294002 inhibits glucocorticoid-induced COX-2 gene expression in cardiomyocytes through a phosphatidylinositol 3 kinase-independent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
44. [Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
45. [Lead induces COX-2 expression in glial cells in a NFAT-dependent, AP-1/NFκB-independent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
46. [Transactivation of EGFR/PI3K/Akt involved in ATP‐induced inflammatory protein expression and cell motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
47. [Pivotal role of protein kinase Cdelta in angiotensin II-induced endothelial cyclooxygenase-2 expression: a link to vascular inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35355)
48. ensembl Release 106