# Prostaglandin-endoperoxide synthase 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q21988894](https://www.wikidata.org/wiki/Q21988894)  
**Source**: https://4ort.xyz/entity/prostaglandin-endoperoxide-synthase-2-q21988894


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q05769)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
5. [A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
6. [Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
7. [S-nitrosylation/activation of COX-2 mediates NMDA neurotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
8. [Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
9. [Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
10. [Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
11. [P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
12. [Mechanical Loading in Osteocytes Induces Formation of a Src/Pyk2/MBD2 Complex That Suppresses Anabolic Gene Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
13. [Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
14. [Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
15. [Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
16. [Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
17. [Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
18. [Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
19. [Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
20. [Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
21. [Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
22. [Central control of fever and female body temperature by RANKL/RANK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
23. [Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769)
24. ensembl Release 106