# Proprotein convertase subtilisin/kexin type 9

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21130010](https://www.wikidata.org/wiki/Q21130010)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/PCSK9)  
**Source**: https://4ort.xyz/entity/proprotein-convertase-subtilisin-kexin-type-9


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2364655)
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3137349)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8NBP7)
5. Q20641742
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
7. [The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
8. [Self-association of human PCSK9 correlates with its LDLR-degrading activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
9. [Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
10. [Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
11. [Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
12. [Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
13. [The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
14. [Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
15. [MMP‐2 inhibits PCSK9‐induced degradation of the LDL receptor in Hepa1‐c1c7 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
16. [Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
17. [Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NBP7&geneProductId=UniProtKB:Q8NBP7)
19. [The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NBP7&geneProductId=UniProtKB:Q8NBP7)
20. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NBP7&geneProductId=UniProtKB:Q8NBP7)
21. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
22. [The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
24. [Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
25. [The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NBP7&geneProductId=UniProtKB:Q8NBP7)
26. [Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NBP7&geneProductId=UniProtKB:Q8NBP7)
27. [The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
28. [Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
29. [Functional characterization of Narc 1, a novel proteinase related to proteinase K](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
30. [Proapoptotic effects of NARC 1 (= PCSK9), the gene encoding a novel serine proteinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
31. [A novel loss of function mutation of PCSK9 gene in white subjects with low-plasma low-density lipoprotein cholesterol](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7)
32. ensembl Release 98
33. UMLS 2023
34. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)