# Proprotein convertase subtilisin/kexin type 2

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28557274](https://www.wikidata.org/wiki/Q28557274)  
**Source**: https://4ort.xyz/entity/proprotein-convertase-subtilisin-kexin-type-2-q28557274


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P28841)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28841)
5. [Aberrant processing of human proislet amyloid polypeptide results in increased amyloid formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28841)
6. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28841)
7. [Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28841)
8. [Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28841)
9. [Neuroendocrine protein 7B2 can be inactivated by phosphorylation within the secretory pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28841)
10. [Colocalization of chaperone Cpn60, proinsulin and convertase PC1 within immature secretory granules of insulin-secreting cells suggests a role for Cpn60 in insulin processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28841)
11. [Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28841)
12. [Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28841)
13. [Thyroid hormones selectively regulate the posttranslational processing of prothyrotropin-releasing hormone in the paraventricular nucleus of the hypothalamus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28841)
14. ensembl Release 106