# Proprotein convertase subtilisin/kexin type 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28559559](https://www.wikidata.org/wiki/Q28559559)  
**Source**: https://4ort.xyz/entity/proprotein-convertase-subtilisin-kexin-type-1-q28559559


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P28840)
3. Q20641742
4. [Regulatory Roles of the P Domain of the Subtilisin-like Prohormone Convertases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
5. [Prohormone convertases 1 and 2 process ProPACAP and generate matured, bioactive PACAP38 and PACAP27 in transfected rat pituitary GH4C1 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28840&geneProductId=UniProtKB:P28840)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28840&geneProductId=UniProtKB:P28840)
8. [Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28840&geneProductId=UniProtKB:P28840)
9. [Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28840&geneProductId=UniProtKB:P28840)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
11. [Colocalization of chaperone Cpn60, proinsulin and convertase PC1 within immature secretory granules of insulin-secreting cells suggests a role for Cpn60 in insulin processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
12. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
13. [Adenovirally Encoded Prohormone Convertase-1 Functions in Atrial Myocyte Large Dense Core Vesicles*](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
14. [Immunocytochemical localization of the prohormone convertases PC1 and PC2 in rat prolactin cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
15. [Regional and cellular localization of the neuroendocrine prohormone convertases PC1 and PC2 in the rat central nervous system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
16. [Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
17. [Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
18. [Thyroid hormones selectively regulate the posttranslational processing of prothyrotropin-releasing hormone in the paraventricular nucleus of the hypothalamus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
19. [Altered proinsulin conversion in rat pancreatic islets exposed long-term to various glucose concentrations or interleukin-1beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
20. [Dietary sodium modulates mRNA abundance of enzymes involved in pituitary processing of proopiomelanocortin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
21. [Regulation of pancreatic endocrine cell differentiation by sulphated proteoglycans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
22. [Regulation of the biosynthesis and processing of chromogranins in organotypic slices: influence of depolarization, forskolin and differentiating factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
23. [Gene expression patterns of pro-opiomelanocortin-processing enzymes PC1 and PC2 during postnatal development of rat corticotrophs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
24. [Docosahexaenoic acid significantly stimulates immediate early response genes and neurite outgrowth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
25. [Regulation of prohormone convertases in hypothalamic neurons: implications for prothyrotropin-releasing hormone and proopiomelanocortin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
26. [Regulation of prohormone convertase 1 (PC1) by gp130-related cytokines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
27. [Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addict](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
28. [Gene expression alterations of neurotrophins, their receptors and prohormone convertases in a rat model of spinal cord contusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
29. [Mutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
30. [Gene Expression of Proprotein Convertases in Individual Rat Anterior Pituitary Cells and Their Regulation in Corticotrophs Mediated by Glucocorticoids](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28840)
31. ensembl Release 106