# Proliferating cell nuclear antigen

> mammalian protein found in Homo sapiens

**Wikidata**: [Q418732](https://www.wikidata.org/wiki/Q418732)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Proliferating_cell_nuclear_antigen)  
**Source**: https://4ort.xyz/entity/proliferating-cell-nuclear-antigen


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P12004)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
6. [Proliferating cell nuclear antigen (PCNA) may function as a double homotrimer complex in the mammalian cell](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
7. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
8. [RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
9. [Tyrosine phosphorylation controls PCNA function through protein stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
11. [DNA polymerase POLN participates in cross-link repair and homologous recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
12. [CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
13. [Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
14. [Polyubiquitinated PCNA Recruits the ZRANB3 Translocase to Maintain Genomic Integrity after Replication Stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
15. [Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
16. [Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
17. [A defined human system that supports bidirectional mismatch-provoked excision](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
18. [Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
19. [Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
20. [DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
21. [Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
22. [Spartan/C1orf124, a Reader of PCNA Ubiquitylation and a Regulator of UV-Induced DNA Damage Response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
23. [Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
24. [Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
25. [A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
26. [Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
27. [The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
28. [PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
29. [The ADP-ribosyltransferase PARP10/ARTD10 interacts with proliferating cell nuclear antigen (PCNA) and is required for DNA damage tolerance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
30. [Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
31. [Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
32. [Replication-independent chromatin loading of Dnmt1 during G2 and M phases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
33. [The HARP-like Domain-Containing Protein AH2/ZRANB3 Binds to PCNA and Participates in Cellular Response to Replication Stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
34. [DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
35. [Inhibition of homologous recombination by the PCNA-interacting protein PARI](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
36. [Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
37. [Spartan/C1orf124 is important to prevent UV-induced mutagenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
38. [Metnase promotes restart and repair of stalled and collapsed replication forks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
39. [ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
40. [Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
41. [WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
42. [Affinity proteomics reveals human host factors implicated in discrete stages of LINE-1 retrotransposition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
43. [An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
44. [ING2 controls the progression of DNA replication forks to maintain genome stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
45. [The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
46. [Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
47. [Complex formation between hepatitis C virus core protein and p21Waf1/Cip1/Sdi1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
48. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
49. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)
50. [Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12004)