# Programmed cell death 6

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21112089](https://www.wikidata.org/wiki/Q21112089)  
**Source**: https://4ort.xyz/entity/programmed-cell-death-6-q21112089


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O75340)
3. Q20641742
4. [Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
6. [The Ca2+-binding protein ALG-2 is recruited to endoplasmic reticulum exit sites by Sec31A and stabilizes the localization of Sec31A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
7. [ALG-2 oscillates in subcellular localization, unitemporally with calcium oscillations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
8. [Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
9. [Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
10. [ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
11. [VPS37 Isoforms Differentially Modulate the Ternary Complex Formation of ALIX, ALG-2, and ESCRT-I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75340&geneProductId=UniProtKB:O75340)
13. [The calcium-binding protein ALG-2 promotes endoplasmic reticulum exit site localization and polymerization of Trk-fused gene (TFG) protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
14. [Structural and Functional Study of Apoptosis-linked Gene-2·Heme-binding Protein 2 Interactions in HIV-1 Production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
15. [Structural Analysis of the Complex between Penta-EF-Hand ALG-2 Protein and Sec31A Peptide Reveals a Novel Target Recognition Mechanism of ALG-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
16. [ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
17. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
18. [Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K/mTOR/p70S6K pathway by interacting of VEGFR-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
19. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
20. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
21. [Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
22. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
23. [HD-PTP and Alix share some membrane-traffic related proteins that interact with their Bro1 domains or proline-rich regions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
24. [A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
25. [Programmed cell death 6 (PDCD6) protein interacts with death-associated protein kinase 1 (DAPk1): additive effect on apoptosis via caspase-3 dependent pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
26. [Penta-EF-hand protein ALG-2 functions as a Ca2+-dependent adaptor that bridges Alix and TSG101](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
27. [Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
28. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75340&geneProductId=UniProtKB:O75340)
29. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75340&geneProductId=UniProtKB:O75340)
30. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75340&geneProductId=UniProtKB:O75340)
31. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75340&geneProductId=UniProtKB:O75340)
32. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
33. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
34. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
35. [Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340)
36. Ensembl Release 99
37. Transporter Classification database