procollagen-proline 4-dioxygenase complex
type: Thing
alternate name: GO:0016222
alternate name: Prolyl hydroxylase
alternate name: procollagen-proline, 2-oxoglutarate-4-dioxygenase complex
alternate name: Procollagen-proline dioxygenase
description: protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate
additional property: PropertyValue
  property ID: P31
  value: cellular component
additional property: PropertyValue
  property ID: P31
  value: group or class of enzymes
additional property: PropertyValue
  property ID: P279
  value: oxidoreductase complex
additional property: PropertyValue
  property ID: P279
  value: oxidoreductase
additional property: PropertyValue
  property ID: P279
  value: endoplasmic reticulum protein-containing complex
additional property: PropertyValue
  property ID: P373
  value: Procollagen-proline dioxygenase
additional property: PropertyValue
  property ID: P486
  value: D011393
additional property: PropertyValue
  property ID: P591
  value: 1.14.11.2
additional property: PropertyValue
  property ID: P646
  value: /m/03cr_l1
additional property: PropertyValue
  property ID: P672
  value: D08.811.682.690.416.617.750
additional property: PropertyValue
  property ID: P672
  value: D08.811.682.690.708.694.750
additional property: PropertyValue
  property ID: P680
  value: procollagen-proline 4-dioxygenase activity
additional property: PropertyValue
  property ID: P686
  value: GO:0016222
additional property: PropertyValue
  property ID: P2888
  value: http://purl.obolibrary.org/obo/GO_0016222
additional property: PropertyValue
  property ID: P2892
  value: C0033384
additional property: PropertyValue
  property ID: P6366
  value: 2780270011
additional property: PropertyValue
  property ID: P6366
  value: 2909287186
confidence:
  popularity graph score:
    score: 0.008
    score pct: 1
    tier: established
    components:
      sitelinks: 8
      sitelinks norm: 0.019
      unique citations: 7
      unique citations norm: 0.003
      monthly pageviews: 46
      monthly pageviews norm: 0.0
  sitelinks: 8
  unique citations: 7
  monthly pageviews: 46
  yearly pageviews: 91
  pageview trend:
    m: 2026-08
    v: 46
  pageview trend:
    m: 2026-07
    v: 11
  pageview trend:
    m: 2026-06
    v: 10
  pageview trend:
    m: 2026-05
    v: 4
  pageview trend:
    m: 2026-05
    v: 1
  pageview trend:
    m: 2026-05
    v: 1
  pageview trend:
    m: 2026-04
    v: 15
  pageview trend:
    m: 2026-04
    v: 2
  pageview trend:
    m: 2026-04
    v: 1
  popularity:
    sitelinks: 8
    max: 423
    pct: 1.9
  tier: established
claims:
  P31:
    value: Q5058355
    source count: 1
    confidence: 0.2
    value label: cellular component
  P31:
    value: Q67015883
    source count: 1
    confidence: 0.2
    value label: group or class of enzymes
  P279:
    value: Q22326951
    source count: 1
    confidence: 0.2
    value label: oxidoreductase complex
  P279:
    value: Q407479
    source count: 1
    confidence: 0.2
    value label: oxidoreductase
  P279:
    value: Q112998243
    source count: 1
    confidence: 0.2
    value label: endoplasmic reticulum protein-containing complex
  P373:
    value: Procollagen-proline dioxygenase
    source count: 0
    confidence: 0.0
  P486:
    value: D011393
    source count: 0
    confidence: 0.0
  P591:
    value: 1.14.11.2
    source count: 1
    confidence: 0.2
  P646:
    value: /m/03cr_l1
    source count: 1
    confidence: 0.2
  P672:
    value: D08.811.682.690.416.617.750
    source count: 0
    confidence: 0.0
  P672:
    value: D08.811.682.690.708.694.750
    source count: 0
    confidence: 0.0
  P680:
    value: Q21118029
    source count: 2
    confidence: 0.4
    value label: procollagen-proline 4-dioxygenase activity
  P686:
    value: GO:0016222
    source count: 1
    confidence: 0.2
  P2888:
    value: http://purl.obolibrary.org/obo/GO_0016222
    source count: 1
    confidence: 0.2
  P2892:
    value: C0033384
    source count: 1
    confidence: 0.2
  P6366:
    value: 2780270011
    source count: 0
    confidence: 0.0
  P6366:
    value: 2909287186
    source count: 0
    confidence: 0.0
citations:
  retrieved: 2019-09-09
citations:
  source: Freebase Data Dumps
  stated in qid: Q15241312
  pub year: 2013
citations:
  source: Gene Ontology release 2019-10-07
  stated in qid: Q70472376
  retrieved: 2019-10-12
citations:
  source: Gene Ontology release 2022-07-01
  stated in qid: Q112968510
  retrieved: 2022-07-14
citations:
  source: UMLS 2023
  stated in qid: Q118645236
  retrieved: 2023-05-24
citations:
  source: Gene Ontology release 2019-07-01
  stated in qid: Q66091208

source: InterPro release 2019-Nov-12
stated in qid: Q77546004

wikidata id: Q21118234
domain: cellular_component
level: standard
html url: https://4ort.xyz/entity/procollagen-proline-4-dioxygenase-complex
markdown url: https://4ort.xyz/entity/procollagen-proline-4-dioxygenase-complex.md
facts url summary: https://4ort.xyz/entity/procollagen-proline-4-dioxygenase-complex/facts.json
facts url standard: https://4ort.xyz/entity/procollagen-proline-4-dioxygenase-complex/facts.json
facts url full: https://4ort.xyz/entity/procollagen-proline-4-dioxygenase-complex/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T08:53:28.673962Z
entity updated at: 2026-05-03T23:45:09.469384+00:00Z
entity created at: 2026-04-11T00:01:31.698717+00:00Z