# Pro-apoptotic WT1 regulator

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21110969](https://www.wikidata.org/wiki/Q21110969)  
**Source**: https://4ort.xyz/entity/pro-apoptotic-wt1-regulator


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q96IZ0)
3. Q20641742
4. [A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96IZ0)
5. [AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96IZ0)
6. [p62 forms a ternary complex with PKCζ and PAR‐4 and antagonizes PAR‐4‐induced PKCζ inhibition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96IZ0)
7. [The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96IZ0)
8. [Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96IZ0)
9. [Multimolecular complex of Par-4 and E2F1 binding to Smac promoter contributes to glutamate-induced apoptosis in human- bone mesenchymal stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96IZ0)
10. [The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96IZ0)
11. [Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96IZ0)
12. [PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96IZ0)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96IZ0)
14. [A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96IZ0&geneProductId=UniProtKB:Q96IZ0)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96IZ0&geneProductId=UniProtKB:Q96IZ0)
16. [AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96IZ0&geneProductId=UniProtKB:Q96IZ0)
17. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96IZ0)
18. [Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96IZ0)
19. Ensembl Release 99