# Pro-apoptotic WT1 regulator

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28561869](https://www.wikidata.org/wiki/Q28561869)  
**Source**: https://4ort.xyz/entity/pro-apoptotic-wt1-regulator-q28561869


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q62627)
3. Q20641742
4. [Par-4-mediated recruitment of Amida to the actin cytoskeleton leads to the induction of apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
5. [Regulation of the expression of prostate apoptosis response protein 4 (Par-4) in rat granulosa cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
6. [Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
7. [Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
8. [Prostate-apoptosis response-4 phosphorylation in vascular smooth muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
9. [The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
10. [Par-4: a new activator of myosin phosphatase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
12. [Immunohistochemical analysis of the proapoptotic protein Par-4 in normal rat tissues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
13. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
14. [Binding of Par-4 to the actin cytoskeleton is essential for Par-4/Dlk-mediated apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
15. [Cellular expression pattern of the protease-activated receptor 4 in the hippocampus in naïve rats and after global ischaemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
16. [Prostate apoptosis response-4 production in synaptic compartments following apoptotic and excitotoxic insults: evidence for a pivotal role in mitochondrial dysfunction and neuronal degeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
17. [Protease-activated receptor subtype expression in developing eye and adult retina of the rat after optic nerve crush](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
18. [Long-term melatonin or 17beta-estradiol supplementation alleviates oxidative stress in ovariectomized adult rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
19. [Differential expression, time course and distribution of four PARs in rats with endotoxin-induced acute lung injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
20. [Prostate apoptosis response-4 mediates trophic factor withdrawal-induced apoptosis of hippocampal neurons: actions prior to mitochondrial dysfunction and caspase activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
21. [Evidence for the involvement of Par-4 in ischemic neuron cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
22. [The pronociceptive effect of proteinase-activated receptor-4 stimulation in rat knee joints is dependent on mast cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
23. [Protease-activated receptor-4: a novel mechanism of inflammatory pain modulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
24. [Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
25. [Interleukin-1β Increased the Expression of Protease-Activated Receptor 4 mRNA and Protein in Dorsal Root Ganglion Neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
26. [Identification of protease-activated receptor-4 (PAR-4) in puromycin-purified brain capillary endothelial cells cultured on Matrigel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
27. [Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease-activated receptors (PARs): a novel role for PAR-4 as opposed to PAR-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
28. [Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
29. [Proteinase-activated receptor-4 (PAR4) activation leads to sensitization of rat joint primary afferents via a bradykinin B2 receptor-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62627)
30. ensembl Release 104