Prion protein
type: Thing
description: mammalian protein found in Rattus norvegicus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P13852
additional property: PropertyValue
  property ID: P361
  value: prion protein family
additional property: PropertyValue
  property ID: P361
  value: Prion/Doppel beta-ribbon domain superfamily
additional property: PropertyValue
  property ID: P361
  value: membrane protein
additional property: PropertyValue
  property ID: P527
  value: Major prion protein N-terminal domain
additional property: PropertyValue
  property ID: P527
  value: Prion/Doppel protein, beta-ribbon domain
additional property: PropertyValue
  property ID: P637
  value: NP_036763
additional property: PropertyValue
  property ID: P637
  value: XP_006235124
additional property: PropertyValue
  property ID: P637
  value: XP_038960208
additional property: PropertyValue
  property ID: P680
  value: amyloid-beta binding
additional property: PropertyValue
  property ID: P680
  value: protease binding
additional property: PropertyValue
  property ID: P680
  value: copper ion binding
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: endoplasmic reticulum
additional property: PropertyValue
  property ID: P681
  value: Golgi apparatus
additional property: PropertyValue
  property ID: P682
  value: negative regulation of protein phosphorylation
additional property: PropertyValue
  property ID: P682
  value: response to oxidative stress
additional property: PropertyValue
  property ID: P682
  value: learning or memory
additional property: PropertyValue
  property ID: P702
  value: Prnp
additional property: PropertyValue
  property ID: P703
  value: brown rat
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000028881
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 19
      unique citations norm: 0.007
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 19
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P13852
    source count: 1
    confidence: 0.2
  P361:
    value: Q24724413
    source count: 1
    confidence: 0.2
    value label: prion protein family
  P361:
    value: Q41798019
    source count: 1
    confidence: 0.2
    value label: Prion/Doppel beta-ribbon domain superfamily
  P361:
    value: Q423042
    source count: 1
    confidence: 0.2
    value label: membrane protein
  P361:
    value: Q83145889
    source count: 1
    confidence: 0.2
    value label: Prion/Doppel protein, beta-ribbon domain, protein family
  P361:
    value: Q83132629
    source count: 1
    confidence: 0.2
    value label: Major prion protein N-terminal domain, protein family
  P527:
    value: Q24720778
    source count: 1
    confidence: 0.2
    value label: Major prion protein N-terminal domain
  P527:
    value: Q24777004
    source count: 1
    confidence: 0.2
    value label: Prion/Doppel protein, beta-ribbon domain
  P637:
    value: NP_036763
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006235124
    source count: 1
    confidence: 0.2
  P637:
    value: XP_038960208
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001382587
    source count: 1
    confidence: 0.2
  P680:
    value: Q14890311
    source count: 2
    confidence: 0.4
    value label: amyloid-beta binding
  P680:
    value: Q14758894
    source count: 2
    confidence: 0.4
    value label: protease binding
  P680:
    value: Q14817980
    source count: 3
    confidence: 0.6
    value label: copper ion binding
  P680:
    value: Q167149
    source count: 1
    confidence: 0.2
    value label: protein binding
  P680:
    value: Q14907450
    source count: 2
    confidence: 0.4
    value label: lamin binding
  P681:
    value: Q79899
    source count: 2
    confidence: 0.4
    value label: cytoplasm
  P681:
    value: Q79927
    source count: 1
    confidence: 0.2
    value label: endoplasmic reticulum
  P681:
    value: Q83181
    source count: 2
    confidence: 0.4
    value label: Golgi apparatus
  P681:
    value: Q220599
    source count: 2
    confidence: 0.4
    value label: cytosol
  P681:
    value: Q29548
    source count: 4
    confidence: 0.8
    value label: plasma membrane
  P682:
    value: Q14860865
    source count: 1
    confidence: 0.2
    value label: negative regulation of protein phosphorylation

value: Q14599315
source count: 2
confidence: 0.4
value label: response to oxidative stress

value: Q14819853
source count: 3
confidence: 0.6
value label: learning or memory

value: Q14819863
source count: 1
confidence: 0.2
value label: positive regulation of cell death

value: Q14860896
source count: 1
confidence: 0.2
value label: protein destabilization

value: Q24381678
source count: 1
confidence: 0.2
value label: Prnp

value: Q184224
source count: 1
confidence: 0.2
value label: brown rat

value: ENSRNOP00000028881
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-02-14

source: Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein
stated in qid: Q28570280
retrieved: 2019-02-14

source: Cellular prion protein localizes to the nucleus of endocrine and neuronal cells and interacts with structural chromatin components
stated in qid: Q29347112
retrieved: 2019-02-14

source: Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein
stated in qid: Q24322990
retrieved: 2019-02-14

source: Rdj2, a J protein family member, interacts with cellular prion PrP(C)
stated in qid: Q28581197
retrieved: 2019-02-14

source: Interaction between the cellular prion (PrPC) and the 2P domain K+ channel TREK-1 protein
stated in qid: Q28583752
retrieved: 2019-02-14

source: Pronounced cytosolic aggregation of cellular prion protein in pancreatic beta-cells in response to hyperglycemia
stated in qid: Q28577028
retrieved: 2019-02-14

source: The membrane environment of endogenous cellular prion protein in primary rat cerebellar neurons
stated in qid: Q28564427
retrieved: 2019-02-14

source: Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons
stated in qid: Q28771398
retrieved: 2019-02-14

source: The interaction between prion protein and laminin modulates memory consolidation
stated in qid: Q28277933
retrieved: 2019-02-14

source: Doppel-induced apoptosis and counteraction by cellular prion protein in neuroblastoma and astrocytes
stated in qid: Q28575635
retrieved: 2019-02-14

source: Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1
stated in qid: Q28910209
retrieved: 2019-02-14

source: Induction of cellular prion protein gene expression by copper in neurons
stated in qid: Q28584119
retrieved: 2019-02-14

source: Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein
stated in qid: Q28771710
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2021-11-17

source: Q20641742
stated in qid: Q20641742
retrieved: 2021-09-07

source: ensembl Release 104
stated in qid: Q106833387

wikidata id: Q28556940
domain: protein
level: standard
html url: https://4ort.xyz/entity/prion-protein
markdown url: https://4ort.xyz/entity/prion-protein.md
facts url summary: https://4ort.xyz/entity/prion-protein/facts.json
facts url standard: https://4ort.xyz/entity/prion-protein/facts.json
facts url full: https://4ort.xyz/entity/prion-protein/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-23T22:18:12.224878Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:58:40.809833+00:00Z