# Prion protein

> mammalian protein found in Mus musculus

**Wikidata**: [Q14881308](https://www.wikidata.org/wiki/Q14881308)  
**Source**: https://4ort.xyz/entity/prion-protein-q14881308


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P04925)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
5. [Expression of prion protein increases cellular copper binding and antioxidant enzyme activities but not copper delivery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
6. [Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
7. [Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
9. [Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
10. [The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
11. [The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
12. [PrPC directly interacts with proteins involved in signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
13. [Prion protein interaction with the C-terminal SH3 domain of Grb2 studied using NMR and optical spectroscopy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
14. [Novel assay with fluorescence‐labelled PrP peptides for differentiating L‐type atypical and classical BSEs, and scrapie](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
15. [Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC α(2)δ-1 Subunit](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
16. [Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
17. [The effect of β2‐α2 loop mutation on amyloidogenic properties of the prion protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
18. [Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
19. [Tetracysteine-tagged prion protein allows discrimination between the native and converted forms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
20. [Prion disease susceptibility is affected by  -structure folding propensity and local side-chain interactions in PrP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
21. [Natural and synthetic prion structure from X-ray fiber diffraction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
22. [Formation of amyloid fibrils from β‐amylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
23. [Early onset prion disease from octarepeat expansion correlates with copper binding properties](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
24. [Cellular Phenotyping of Secretory and Nuclear Prion Proteins Associated with Inherited Prion Diseases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
25. [Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
26. [Copper stimulates endocytosis of the prion protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
27. [The binding of prion proteins to serum components is affected by detergent extraction conditions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
28. [Scrapie-infected mice and PrP knockout mice share abnormal localization and activity of neuronal nitric oxide synthase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
29. [Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
30. [Pharmacological prion protein silencing accelerates central nervous system autoimmune disease via T cell receptor signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
31. [Unusual property of prion protein unfolding in neutral salt solution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
32. [Memory impairment in transgenic Alzheimer mice requires cellular prion protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
33. [Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
34. [Mammalian prion protein suppresses Bax-induced cell death in yeast](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04925)
35. ensembl Release 106