# Presenilin 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q21988969](https://www.wikidata.org/wiki/Q21988969)  
**Source**: https://4ort.xyz/entity/presenilin-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q61144)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
5. [Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144)
6. [Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144)
7. [Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144)
8. [Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
9. [Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
10. [Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
11. [Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
12. [Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
13. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
14. [A role for the primary cilium in Notch signaling and epidermal differentiation during skin development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
15. [Profiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144)
17. [Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144)
18. [Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144)
19. [An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144)
20. [Spatial segregation of gamma-secretase and substrates in distinct membrane domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
21. [Cell-fate decisions in early T cell development: regulation by cytokine receptors and the pre-TCR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
22. [Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
23. [Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
24. [Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
25. [Mice lacking both presenilin genes exhibit early embryonic patterning defects](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
26. [Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
27. [Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
28. [Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
29. [Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
30. [Presenilins regulate alphabeta T cell development by modulating TCR signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
31. [gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
32. [Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
33. [Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
34. [Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
35. [Presenilin 1 is required for maturation and cell surface accumulation of nicastrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
36. [Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
37. [Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
38. [Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144)
39. [Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
40. [Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
41. [Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61144&geneProductId=UniProtKB:Q61144)
42. [Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
43. [Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61144)
44. ensembl Release 106