# Presenilin 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21108557](https://www.wikidata.org/wiki/Q21108557)  
**Source**: https://4ort.xyz/entity/presenilin-2-q21108557


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P49810)
3. Q20641742
4. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810)
6. [Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810)
7. [Interactome mapping suggests new mechanistic details underlying Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810)
8. [A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810)
9. [Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810)
11. [Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810)
12. [Purification and characterization of the human gamma-secretase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810)
13. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810)
14. [Purification and characterization of the human gamma-secretase complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810)
15. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810)
16. [The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810)
17. [Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810)
18. Ensembl Release 99
19. Transporter Classification database