# Presenilin 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4377404](https://www.wikidata.org/wiki/Q4377404)  
**Source**: https://4ort.xyz/entity/presenilin-1


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P49768)
4. Q20641742
5. [Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
8. [The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768)
9. [Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768)
10. [Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
11. [Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
12. [Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
13. [X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
14. [Cellular localization of Nicastrin affects amyloid beta species production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
15. [Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
16. [Interactome mapping suggests new mechanistic details underlying Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
17. [TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
18. [Activation and intrinsic γ-secretase activity of presenilin 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
19. [Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
20. [Intracellular trafficking of TREM2 is regulated by presenilin 1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
21. [Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
22. [Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
23. [Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
24. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768)
25. [Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768)
26. [An atomic structure of human γ-secretase](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768)
27. [Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
28. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49768&geneProductId=UniProtKB:P49768)
29. [Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49768&geneProductId=UniProtKB:P49768)
30. [The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
31. [Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
32. [Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
33. [An atomic structure of human γ-secretase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
34. [Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
35. [Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
36. [Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
37. [Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
38. [The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
39. [Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
40. [Two homologous genes causing early-onset familial Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768)
41. [Purification and characterization of the human gamma-secretase complex](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768)
42. [Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
43. [Two homologous genes causing early-onset familial Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
44. [Purification and characterization of the human gamma-secretase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
45. [Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
46. [A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
47. [Role of presenilin1 in structural plasticity of cortical dendritic spines in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)
48. [Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768)
49. [Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768)
50. [Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768)