# Presenilin 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28560529](https://www.wikidata.org/wiki/Q28560529)  
**Source**: https://4ort.xyz/entity/presenilin-1-q28560529


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P97887)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97887)
5. [Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97887)
6. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97887)
7. [Proteomic and metabolomic analyses of mitochondrial complex I-deficient mouse model generated by spontaneous B2 short interspersed nuclear element (SINE) insertion into NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97887)
8. [Transient abundance of presenilin 1 fragments/nicastrin complex associated with synaptogenesis during development in rat cerebellum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97887)
9. [Presenilin-1 is located in rat mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97887)
10. [Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97887)
11. [Synaptic and endosomal localization of active gamma-secretase in rat brain](http://www.ebi.ac.uk/QuickGO/annotations?protein=P97887&geneProductId=UniProtKB:P97887)
12. [Synaptic and endosomal localization of active gamma-secretase in rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97887)
13. [Detection of the presenilin 1 COOH-terminal fragment in the extracellular compartment: a release enhanced by apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97887)
14. [Normal distribution of presenilin-1 and nicastrin in skeletal muscle and the differential responses of these proteins after denervation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97887)
15. [Shedding of the p75NTR neurotrophin receptor is modulated by lipid rafts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97887)
16. [Developmental regulation and possible alternative cleavage of presenilin 1 in the rat retina](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97887)
17. [Presenilin-1 protects against neuronal apoptosis caused by its interacting protein PAG](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97887)
18. ensembl Release 106