# Pre B cell leukemia homeobox 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21988411](https://www.wikidata.org/wiki/Q21988411)  
**Source**: https://4ort.xyz/entity/pre-b-cell-leukemia-homeobox-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P41778)
3. Q20641742
4. [Prep2: cloning and expression of a new prep family member](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
6. [Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
7. [Meis Proteins are Major In Vivo DNA Binding Partners for Wild-Type but Not Chimeric Pbx Proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
8. [A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
9. [Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
10. [Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
11. [Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
12. [Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
13. [Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
14. [PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41778&geneProductId=UniProtKB:P41778)
15. [Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41778&geneProductId=UniProtKB:P41778)
16. [PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
17. [Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
18. [The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
19. [Hox proteins display a common and ancestral ability to diversify their interaction mode with the PBC class cofactors.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
20. [Expression of Hox cofactor genes during mouse ovarian follicular development and oocyte maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
21. [Nonmuscle myosin promotes cytoplasmic localization of PBX](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
22. [Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
23. [Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
24. [A conformational change in PBX1A is necessary for its nuclear localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
25. [Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
26. [Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
27. [Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
28. [Altered neuronal lineages in the facial ganglia of Hoxa2 mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
29. [Pbx1 is essential for adrenal development and urogenital differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
30. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41778&geneProductId=UniProtKB:P41778)
31. [Pbx1 regulates nephrogenesis and ureteric branching in the developing kidney](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
32. [The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41778)
33. ensembl Release 106